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Laser Therapy & Nerve Regeneration
How it works... Low level laser has neuro-regenerative and neuro-protective effects - There is massive axonal sprouting and increased survival times after LLLT - There is increased synthesis of various molecules such as growth-associated-protein-43 (GAP-43), calcitonin gene-related peptide (CGRP), and transforming growth factor beta1. - There are neuroprotective effects exerted by the latter two molecules, together with suppressed nitric oxide (NO) activity (a neurotoxic agent) therefore reducing cell death of axotomized neurons. - Post-traumatic chromatolysis and neuronal atrophy of motorneurons are less extensive after low level laser biostimulation at the nerve site - There is evidence that light may enhance recovery of neurons from injury by altering mitochondrial oxidative metabolism Low power laser effects on the non-neuronal component of the nerve - Laser irradiation directly stimulates the proliferation of rat Schwann cells which are a key factor for successful nerve recovery. - Laser irradiation also stimulates proliferation of macrophages and fibroblasts. These play a key role during Wallerian degeneration and are responsible for the generation of collagen fibrils that form the scaffold of Reference:
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