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Low Level Laser Therapy (LLLT) news
January 17th, 2010 07:33 PM
Some very interesting papers in this edition including a large back pain RCT of 546 patients, LLLT for major depression and anxiety from Harvard Medical School, Allergic Rhinitis and another from Harvard on mechanism and dose.
Acute Low Back Pain with Radiculopathy: A Double-Blind, Randomized, Placebo-Controlled Study.
Konstantinovic LM, Kanjuh ZM, Milovanovic AN, Cutovic MR, Djurovic [...]
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January 5th, 2010 06:26 PM
Somehow this paper slipped through the net and missed my literature watch last year
Low-level laser irradiation promotes the recovery of atrophied gastrocnemius skeletal muscle in rats.
Nakano J, Kataoka, H, Sakamoto J, Origuchi T, Okita M, Yoshimura T
Unit of Physical Therapy and Occupational Therapy Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8052, Japan.
Low-level laser [...]
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December 31st, 2009 08:17 AM
Wow, what a decade it has been for LLLT. Credibility is critical for acceptance by reimbursement and regulatory authorities as well as doctors and therapists. In the last ten years over 1,000 papers have been published that build on the work of the early pioneers. Highlights of this decade include: FDA clearance, publication in high [...]
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December 31st, 2009 02:45 AM
Because LLLT modulates cellular oxidation and energy production it could potentially affect a wide range of diseases, injuries or other dysfunctions in the body.
By the end of the next decade, it is possible LLLT may be used in almost every department of every hospital (and every medicine cabinet of every home).
Given the amount of good [...]
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December 6th, 2009 05:39 AM
62 LLLT abstracts for you this month and of course we have to start with the Lancet paper on laser for neck pain. You can see a TV interview with the primary author Roberta Chow on the front page of our web site and an audio interview I did back in September is here. There [...]
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Infrared light may reverse dementia and memory loss
That was the big claim British researchers made last month in what appears to be a global PR / news story that was covered substantially by the popular press.The news / PR reports claim that regular exposure to low-level infra-red light can improve learning performance and trigger regeneration of the cognitive function of the brain.
Our attempts to find the related published research produced by this group led us to just one paper showing that IR light improves "acquisition of working memory spatial navigation" in CD1 mice. The headlines that have been generated are quite bold given the limited published material but we cautious welcome this news.
Read research here >>
Human testing is due to start summer 2008 they say.
More here >>
Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination time
Lasers Surg Med. 2007 Jul;39(6):543-50
Castano AP et al
BACKGROUND: It has been proposed for many years that low-level laser
(or light) therapy (LLLT) can ameliorate the pain, swelling, and inflammation
associated with various forms of arthritis. Light is thought to be absorbed
by mitochondrial chromophores leading to an increase in adenosine triphosphate
(ATP), reactive oxygen species and/or cyclic AMP production and consequent
gene transcription via activation of transcription factors. However, despite
many reports about the positive effects of LLLT in arthritis and in medicine
in general, its use remains controversial. For all indications (including
arthritis) the optimum optical parameters have been difficult to establish
and so far are unknown. METHODS: We tested LLLT on rats that had zymosan
injected into their knee joints to induce inflammatory arthritis. We compared
illumination regimens consisting of a high and low fluence (3 and 30 J/cm(2)),
delivered at high and low irradiance (5 and 50 mW/cm(2)) using 810-nm
laser light daily for 5 days, with the positive control of conventional
corticosteroid (dexamethasone) therapy. RESULTS: Illumination with 810-nm
laser was highly effective (almost as good as dexamethasone) at reducing
swelling and a longer illumination time (10 or 100 minutes compared to
1 minute) was more important in determining effectiveness than either
the total fluence delivered or the irradiance. LLLT induced reduction
of joint swelling correlated with reduction in the inflammatory marker
serum prostaglandin E2 (PGE2). CONCLUSION: LLLT with 810-nm laser is highly
effective in treating inflammatory arthritis in this model. Longer illumination
times were more effective than short times regardless of total fluence
or irradiance. These data will be of value in designing clinical trials
of LLLT for various arthritides.
Light Promotes Regeneration and Functional Recovery and Alters the Immune Response After Spinal Cord Injury
Photobiomodulation (PBM) has been proposed as a potential therapy for spinal cord injury (SCI). We aimed to demonstrate that 810 nm light can penetrate deep into the body and promote neuronal regeneration and functional recovery. Adult rats underwent a T9 dorsal hemisection, followed by treatment with an 810 nm, 150mW diode laser (dosage¼1,589 J/cm2). Axonal regeneration and functional recovery were assessed using single and double label tract tracing and various locomotor tasks. The immune response within the spinal cord was also assessed.
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Ottawa Panel Evidence-Based Clinical Practice Guidelines for Electrotherapy and Thermotherapy Interventions in the Management of Rheumatoid Arthritis in Adults
The purpose of this project was to create guidelines for electrotherapy and thermotherapy interventions in the management of adult patients (>18 years of age) with a diagnosis of rheumatoid arthritis according to the criteria of the American Rheumatism Association (1987).Using Cochrane Collaboration methods, the Ottawa Methods Group identified and synthesized evidence from comparative controlled trials. The group then formed an expert panel, which developed a set of criteria for grading the strength of the evidence and the recommendation. Patient-important outcomes were determined through consensus, provided that these outcomes were assessed with a validated and reliable scale...
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Liko Is One Lucky Dolphin
To Save Dolphin's Dorsal Fin, Experts Combine Human Medical Technology and Teamwork. Dolphin Quest Enlists University of Pittsburgh Specialist to Develop Custom 'Scaffold' for Tissue's Repair.
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An expert team of marine mammal veterinarians, medical researchers, cosmetic surgeons and dolphin trainers recently joined forces to apply the latest advances in human regenerative medicine in an attempt to restore a bottlenose dolphin's damaged dorsal fin. "Liko's story is a story of medicine with a big heart," said Dr. Rae Stone, a Dolphin Quest veterinarian and co-owner. "It shows extraordinary voluntary cooperation across several human medical and veterinary disciplines that has involved numerous experts with cutting-edge technology and specialized experience. Liko is one very lucky young dolphin." The procedure on Liko, a three-year-old male dolphin at Dolphin Quest on Hawaii's Big Island, took place on July 30 and marked the first-ever marine mammal application of extracellular matrix tissue repair. Liko (pronounced Lee-ko) continues to undergo pioneering veterinary LED (light emitting diode) therapy to stimulate tissue growth and regeneration in his injured fin. |
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Low-Intensity Laser Therapy for Benign Fibrotic Lumps in the Breast Following Reduction Mammaplasty
Ethne L Nussbaum
Fibrotic masses in the breast secondary to fat necrosis or hematoma are a complication of breast reduction mammaplasty. The treatment commonly recommended for this condition is early surgical debridement of necrotic tissue from the entire area, which causes scarring. This case report describes the use of low-intensity laser therapy for fibrotic lumps following reduction mammaplasty. The patient was a 46-year-old woman who had breast reduction surgery 80 days prior to referral for physical therapy. At the time of referral, the largest mass was 8.0 cm in diameter. The patient reported pain and said she was distressed about the breast disfigurement.
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Low Level Laser Therapy In The Management Of Chronic Myofascial Pain In The Neck
A Gur, AJ Sarac, R Cevik, O Altindag, and S Sarac
Physical Medicine and Rehabilitation, School of Medicine, Dicle University, Diyarbakir, Turkey.
A prospective, double-blind, randomized, and controlled trial was conducted in patients with chronic myofascial pain syndrome (MPS) in the neck to evaluate the effects of infrared low level 904 nm Gallium-Arsenide (Ga-As) laser therapy (LLLT) on clinical and quality of life (QoL). This study revealed that short-period application of LLLT is effective in pain relief and in the improvement of functional ability and QoL in patients with MPS. Lasers Surg. Med. 35:229-235, 2004.
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Injury can't slow Leap's Reno run
On Jan. 28, while loosening up for the Wednesday Night League at Brownsburg Bowl, Leap crushed the end of the little finger on his right hand, which he uses to bowl. A bone graft was used, six weeks later the pins were removed and the finger still was not healing properly. Two weeks later, he heard about cold laser therapy.
"Mostly chiropractors use it," Leap said. "I found one in Brownsburg who does it. I went to him eight times in two weeks. I then went to the hand center and had it X-rayed again. They said the finger was completely healed. I'm a firm believer in cold laser therapy."
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A new type of very low-power modulated laser:
soft-tissue changes induced in osteoarthritic patients revealed by sonography.
Baratto L, Capra R, Farinelli M, Monteforte P, Morasso P, Rovetta G.
Rehabilitation Division, Hospital La Colletta, Arenzano, ASL 3 Genoa, Italy.
Patients with symptomatic osteoarthritis of the cervical spine were studied by ultrasound examination. The region of interest was the soft connective tissue layer above the right and the left superior trapezium that revealed a significant difference in thickness between the left and right side.
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Low-power laser in osteoarthritis of the cervical spine.
Monteforte P, Baratto L, Molfetta L, Rovetta G.
Rheumatology Department, University of Genova, Bruzzone Rheumatologic Center, Genoa, Italy.
Patients with symptomatic osteoarthritis of the cervical spine were treated with very low-power modulated laser (LPL). Two applications were performed at an interval of 20 days. Changes in pain and ultrasound thickness of the soft connective tissue layer above the right and the left superior trapezium were studied. No worsening of pain was observed. Pain improved after the first application of LPL in 9 out of 14 patients, but the difference was not significant.
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Low-intensity indocyanine-green laser phototherapy of acne vulgaris: Pilot study.
Genina EA, Bashkatov AN, Simonenko GV, Odoevskaya OD, Tuchin VV, Altshuler GB.Saratov State University, Optics Department, Astrakhanskaya 83, Saratov 410026, Russia.
Near infrared (NIR) diode laser low-intensity (soft) phototherapy with the topical application of indocyanine green (ICG) has been suggested for treatment of acne vulgaris. Twelve volunteers with acne lesions on their faces and/or backs were enrolled in the experiment. Skin areas of the subjects that were 4x5 cm² were stained with ICG solution for 5 min before laser irradiation (803 nm) at a power density up to 50 mW/cm² for 5 to 10 min. For 75% of the subjects, a single treatment was provided and for the other 25%, eight sequential treatments over a period of a month were carried out.
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Low-level laser treatment can reduce edema in second degree ankle sprains.
Stergioulas A., Faculty of Human Motion, University of Peloponnese, Attica, Greece. asterg@uop.gr
OBJECTIVE: Low-level laser therapy (LLLT) has been used for the last few years to treat sports injuries. The purpose of this study was to compare three therapeutic protocols in treating edema in second degree ankle sprains that did not require immobilization with a splint, under placebo-controlled conditions. Forty-seven soccer players with second degree ankle sprains, selected at random, were divided into the following groups: The first group (n = 16) was treated with the conventional initial treatment (RICE, rest, ice, compression, elevation), the second group (n = 16) was treated with the RICE method plus placebo laser, and the third group (n = 15) was treated with the RICE method plus an 820-nm GaA1As diode laser with a radiant power output of 40 mW at 16 Hz...
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Transcranial Infrared Laser Therapy Improves Clinical Rating Scores
After Embolic Strokes in Rabbits
Paul A. Lapchak PhD*; Jiandong Wei MD; and Justin A. Zivin MD, PhD
Because photon energy delivered using a low-energy infrared laser may be useful to treat stroke, we determined whether transcranial laser therapy would improve behavioral deficits in a rabbit small clot embolic stroke model (RSCEM). In this study, the behavioral and physiological effects of laser treatment were measured. The RSCEM was used to assess whether low-energy laser treatment (7.5 or 25 mW/cm2) altered clinical rating scores (behavior) when given to rabbits beginning 1 to 24 hours postembolization. Behavioral analysis was conducted from 24 hours to 21 days after embolization, allowing for the determination of the effective stroke dose (P50) or clot amount (mg) that produces neurological deficits in 50% of the rabbits. Using the RSCEM, a treatment is considered beneficial if it significantly increases the P50 compared with the control group.
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Effect of low level laser therapy on the repair of bone defects grafted with inorganic bovine bone
Braz Dent J, January 1, 2003; 14(3): 177-81.
The aim of this study was to assess histologically the effect of LLLT (l 830 nm) on the repair of standardized bone defects on the femur of Wistar albinus rats which were grafted with inorganic bovine bone Gen-ox(R). Three randomized groups were studied: group I (control, n=6); group II (Gen-ox(R), n=9) and group III (Gen-ox(R) + LLLT, n=9). The animals were irradiated every 48 h during 15 days; the first irradiation was performed immediately after the procedure. The animals were irradiated transcutaneuosly at four points around the defect. At each point a dose of 4 J/cm(2) was given (Ø~0.6 mm, 40 mW) and the total dose per session was 16 J/cm(2). The animals were killed by an overdose of general anesthetic 15, 21 and 30 days after surgery.
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Laser Could Ease Pain, Promote Healing
Doctors Use Low-Beam Laser To Treat Injuries, Arthritis, Carpal Tunnel Syndrome
A gentle beam of light can be a powerful weapon against stubborn aches, according to some people who are trying a new low-level laser therapy. Chiropractor Dr. Gary Hartell explained that the treatment uses a gentle beam of light used to ease inflammation and promote healing. He said it is being used to treat all sorts of conditions, including sports injuries, arthritis, carpal tunnel syndrome and even hard-to-heal wounds. "Generally the more acute, more recent injury is going to respond quicker [than] say in several sessions, versus somebody who has had a long-standing chronic problem," Hartell said. Hartell explained how the treatment works: he first uses pinpoint wand to work on acupuncture points.
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New laser procedure touted as cure for carpal tunnel syndrome
By Denise Allabaugh , Citizens' Voice Staff Writer 04/15/2004
Years of stretching pizza dough have caused Paul Adamchick of Trucksville to suffer from a very common work-related injury. Adamchick, 35, whose family owns Pizza Perfect in Trucksville, once suffered from carpal tunnel syndrome, a debilitating wrist condition resulting from nerve entrapment. "I had severe hand cramping. I wouldn't be able to sleep at night. My hand was always numb," Adamchick said.
Thanks to a new treatment called "low-level laser therapy," Adamchick says he has been cured. "I can do anything now. I can do what everybody else can do," Adamchick said. "It works. I'm living proof. It's like I have a new pair of hands." Adamchick underwent the therapy six times at the Newhart Chiropractic Center in Plains. Dr. William Newhart believes laser therapy is the "future of medicine."
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Effect of the clinical application of the GaAlAs laser in the treatment of dentine hypersensitivity
J Clin Laser Med Surg. 2003 Oct;21(5):291-6.
Marsilio AL, Rodrigues JR, Borges AB.
Restorative Dentistry, UNESP School of Dentistry, Sao Jose dos Campos, SP, Brazil.
The aim of this study was to evaluate the effectiveness of the clinical use of the gallium-aluminum-arsenium (GaAlAs) laser at the maximum and minimum energies recommended by the manufacturer for the treatment of dentine hypersensitivity. Dentine hypersensitivity (DH) is a response to a stimulus that would not usually cause pain in a healthy tooth. It is characterized by sharp pain of short duration from the denuded dentin. Its etiology is unknown. The dentin only begins to show sensitivity when exposed to the buccal environment. This exposure can result after removal of the enamel and/or dental cement, or after root denudation. Different treatments are proposed for this disorder.
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Light therapy in the treatment of acne vulgaris
Elman M, Lebzelter J.
Dermatology and Lasers Clinic, Tel Aviv Msq, Caesarea, Israel.
Over the past decade, lasers and light-based systems have become a common modality to treat a wide variety of skin-related conditions, including acne vulgaris. In spite of the various oral and topical treatments available for the treatment of acne, many patients fail to respond adequately or may develop side effects. Therefore, there is a growing demand by patients for a fast, safe, and side-effect-free novel therapy.
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Significant Pain Relief after Low Power Laser Treatment for Knee Osteoarthritis
Lasers Surg Med. 2003;33:5:330-338.
12/29/2003 02:16:00 PM
Low power laser therapy (LPLT) effectively reduces pain and improves function and quality of life in patients with knee osteoarthritis (OA), according to a prospective, double-blind study. Effectiveness appears to be independent of dose and duration of laser treatment. LPLT has become a popular, noninvasive alternative treatment; though its effectiveness in osteoarthritis is still controversial. Conflicting results are likely due to variability in the method of application.
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Light emitting diodes bring relief to young cancer patients; NASA technology used for plant growth now in clinical trials
NASA News Release - 11-05-03
A device using specialized light emitting diodes, based on NASA technology for plant growth in space, is continuing to show promise as a treatment to aid healing of bone marrow transplant patients. Use of the LED apparatus has advanced to the second phase of clinical trials in U.S. and foreign hospitals. Results from the first round of tests were highly encouraging, prompting researchers to expand the trials as they seek approval for the treatment as a standard of care for oral mucositis.
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Pioneers bring hope of cure for paralysis
Sunday Herald - 09 November 2003
Hopes of a breakthrough in treating patients with paralysing back injuries have been raised by a groundbreaking experiment which for the first time fused together a mammals broken spinal cord.
The technique in which Scottish-designed lasers were used to repair the spinal cords of paralysed rats restoring the animals mobility is likely to be tested on humans next year. Professor Juanita Anders, the lead researcher on the project at the Uniformed Services University in Maryland, said that some of the advances in the field of light therapy are almost too incredible to believe.
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Laser May Reduce Arm Swelling After Mastectomy
Fri Oct 10, 2:24 PM ET
NEW YORK (Reuters Health) - The zap of a low-level laser seems to relieve some cases of chronic swelling in the arm that often occurs after a mastectomy, new research suggests. In a study, swelling diminished significantly in nearly a third of women who received laser treatment for the condition, known as lymphedema. "It's not a quick fix, but it does seem to help in some people and is not invasive," Dr. Colin J. Carati, the study's lead author, told Reuters Health. "Lymphedema is a chronic and progressive condition for which there are few effective treatment options," explained Carati, who is at Flinders University in Adelaide, Australia. Low-level laser treatment has proved effective in improving wound healing and scarring, "so we decided to give it a try in lymphedema," he explained.
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Light Therapy for Damaged Retinas
Stephen Leahy of NewScientist.com
Near infra-red light therapy - commonly known as Low Level Laser Therapy- is drawing a lot of attention from research clinicians around the world. For a number of years various researchcenters in Japan, Britain, and the United States have been conducting clinical trials to measure the efficacy of the application of red and near infra-red light over injuries and lesions healing and give relief for both acute and chronic pain. Many of these trials have proven very successful and clearly verified that light can have a positive effect on damaged cells. So much so that the US Defense Advance Research Projects Agency is funding research into the method and hopes to use it to treat some of their personnel whose eyes have been damaged by lasers during combat.
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